BBO-8520, a first-in-class direct dual inhibitor of GTP-bound (ON) and GDP-bound (OFF) KRASG12C, exhibits robust efficacy in non-small cell lung cancer preclinical models

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BBO-8520, a first-in-class, direct, and covalent small molecule inhibitor of GTP-bound (ON) and GDP-bound (OFF) KRASG12C, demonstrates robust efficacy and compares favorably to GDP-bound KRASG12C (OFF) only inhibitors in preclinical models

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BBO-8520, a First-in-Class, Direct Inhibitor of KRASG12C (ON), Locks GTP-Bound KRASG12C in the State 1 Conformation Resulting in Rapid and Complete Blockade of Effector Binding

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